"Breakpoint research? How do you say it?" Lu Cheng has advanced medical statistics, so when he heard Fang Nixin talking about breakpoint research, he still knew the term.

Discontinuity regression model.

But discontinuity regression is mostly used in social sciences!

Social scientists are primarily interested in causal relationships.

In social sciences, randomized trials are restricted by many factors such as ethics and practice. In the absence of randomized trials, we often resort to strict quasi-natural experimental intervention. Among them, the discontinuity regression method is a credible

Causal inference analysis method.

For example, analyze the impact of IQ and college entrance examination scores on a certain person.

This statistical method is rarely used in natural science fields such as medicine.

Discontinuity regression is suitable for whether the use of an intervention method depends entirely on a certain continuous variable. For example, the use of antidiabetic drugs depends on blood sugar levels. This continuous variable is equivalent to a discontinuous function. This discontinuous function completely determines whether an individual is affected by a specific disease.

Intervention.

From 1984, Trochim believed that the application range of discontinuity regression is not so narrow, on the contrary, its application range is very broad. His research results expanded that the key variable in determining intervention can not only be a measured continuous variable, but also a

comprehensive variables.

After him, the advantages of breakpoint regression were gradually recognized by the academic community, and its applications became more widespread.

Its advantages include two aspects: first, discontinuity regression can be used when RCT cannot be carried out due to limitations in research costs and ethical issues; second, discontinuity regression is superior to all other known causal inference methods.

, including the instrumental variable method, the results are very close to the results of random experiments.

Medical research pays attention to objectivity and accuracy, because a certain amount of error can cause different results.

Therefore, Lu Cheng had not considered this method before, because he is a clinician and he does not have that much free time to apply a statistical method that is mostly used in social disciplines in this research group.

However, Professor Min Hong has said before that when your achievements in one subject reach a threshold, you may have to read more books on other subjects and ask for help from other subjects, and you may have an epiphany.

Fang Nixin sent the message very early, Lu Cheng didn't reply to her, and she didn't push her.

But obviously during this period of time, she had made a lot of preparations herself, and her own scientific research qualifications were really better than Lu Cheng, so she sent a message saying:

"This is a question that I suddenly thought about when I was doing biometric analysis of VI-related genotypes that can be found online."

"We can actually conduct breakpoint regression analysis on existing patients. And we can only do breakpoint regression, not RCT."

"We can use different grouping values ​​to analyze the length of hospitalization of patients, the diagnosis and treatment process of deceased patients, etc."

"Breakpoint regression requires a highly idealized environment, but this kind of research obviously cannot be achieved through RCT."

"In addition, we can also actively intervene in the process of doing cell experiments through breakpoints to explore the reproduction and growth rates of cells, and then analyze the pathways within them. I believe we can also more quickly

Found some useful information…”

Fang Nixin sent a paragraph, and then said: "This is my revised plan based on the experimental direction of our research group. Do you want to take a look?"

"Okay, send it over and let me take a look." Lu Chengcheng went upstairs in no hurry.

Although he has scene skills and Alice is there to help him with experiments, most of the experimental process is carried out through his own suggestions and discussions.

However, Lu Cheng did not dare to say that his research progress and talent were better than others.

After browsing carefully, Lu Chengcheng immediately changed direction.

Said: "Please print out two copies of this plan and the previous plan, and let's discuss them in detail."

The meaning of the existence of the research group is to seek common ground while reserving differences.

It is inevitable to accommodate differences. Everyone has different ideas and thoughts. But Lu Cheng had always worked alone before. Although others formed a temporary research team for him, those people were different from Lu Cheng.

We are familiar with each other, and what Er Lucheng released is too shocking.

For those who are not familiar with Lu Cheng, it is too late to confirm Lu Cheng's conjecture as soon as possible. How can they dare to make changes to Lu Cheng's existing plan?

Is it because Lu Cheng doesn't want to lose face or do they think they can do it?

Even if it is possible, if we drag them to Lu Cheng's position, how many of them will be able to sit still?

When the time comes, Lu Cheng may not be able to help him with all his efforts to create another basic design for him to change. In fact, Lu Cheng was ordered to do so in a critical situation.

This is the inevitable grudge that exists when the members of the research team are strangers.

But Fang Nixin is different. Her relationship with Lu Cheng should be one of the people she is most familiar with. She can put forward her own ideas without any scruples, even if her ideas are adopted and taken seriously.

.

After she was promoted, she could still continue to work with Lu Cheng, come up with the next research plan together, and continue the discussion.

Just like, every time Lu Cheng wanted to announce some results, he would just go to Lin Hui immediately instead of going to Mr. Sheng and Mr. Gui who were more famous than Lin Hui. The reason is the same.

Science has no borders, but scientists do.

Just like this special time, research progress should not be secretive, but should be announced.

However, it is up to the research team to choose who publishes it and how they publish it.

Once again, we came to an office on the 12th floor of the Science and Education Building. It was five floors away from Fang Nixin’s experiment, with many floors in between.

The reason for this arrangement is that the laboratory must not be a place for living and living.

This place has been temporarily transformed into a dormitory, with a simple single bed and a kettle and other necessary supplies. Of course, there is also a large table in the middle of the room, which used to be a desk.

It has been cleared now, and the table is more than two meters wide in all directions.

After Lu Cheng entered the door, he saw so-called documents appearing on both sides of the desk. Moreover, the side where Lu Cheng was sitting had a strong smell of alcohol. Fang Nixin must have disinfected the appearance of the document.

Yes.

Fang Nixin was taking off her gloves at the moment, pointed over there and said:

"Sit over there."

"The cup is clean and brought over after high-temperature sterilization. The water has been boiled for at least half an hour."

"I took the documents wearing examination gloves, and the stool was disinfected."

The current information released about VI is that boiling water can kill VI, and a high temperature environment of 70 degrees can kill VI in 30 minutes.

Just as Lu Cheng was about to say something, Fang Nixin blocked his mouth in advance: "I followed the current management methods for researchers, and I am meticulous. Let's talk about the project first."

Lu Cheng nodded: "Well, okay!"

At eleven o'clock in the night, the lights were bright, and the two of them were sitting on the desk facing each other, and they started to discuss each other sentence by sentence.

There is absolutely no romance at all.

…

About half an hour later, Lu Cheng nodded and asked: "Fang Nixin, do you think this breakpoint regression has certain applicability among people who are currently undergoing treatment and recovering?"

Fang Nixin said: "Retrospective RCT analysis can actually be used for clinically recovered patients. There is no need to use breakpoint regression."

"The greater use of breakpoint regression is in more extreme conditions. Such as death, severe illness, disability..."

Can't you kill, cripple, and cramp people just for the sake of research?

"Okay." Lu Cheng sighed, as if he had almost been assimilated by the advantages of this breakpoint regression analysis, and wanted to apply everything to it.

Lu Cheng then changed the topic and said: "Fang Nixin, I have a huge amount of data here, as well as basic research and design. You can use a computer to help me count it."

"I have used a crawler to crawl out the data. It is already in EXCEL format. All you need to do is analyze it."

Fang Nixin said suspiciously: "It's already in excel format, so you can just analyze it. What's most scary is that the data hasn't been obtained yet, and you can't even analyze it."

However, when Fang Nixin saw clearly the data sent by Lu Cheng and the title of the Word document.

"Statistical analysis of the treatment process of retrospective analysis of 124,581 cases and theoretical basis support for guessing the superior treatment plan."

I immediately understood what Lu Cheng meant.

Feeling a little guilty, she immediately lowered her voice: "Are you planning to take my name?"

Fang Nixin is a sensible person. She has been in a research group before and knows these things very well.

The article should include more authors, or even one author. Many people actually buy articles just for the author and corresponding author.

It's even too much. In China, there is a work for SCI, and there are people who have devoted their lives to it. You know how much benefit and how tempting it is to have an extra name under these heavyweight research.

"You are a member of the research team, and your contribution is the statistics and analysis of data. I will give you the crawler code later, and you can run it on your computer." Lu Cheng made sure that Fang Nixin could legitimately become the

Those who are part of this research are naturally well prepared.

Fang Nixin frowned: "Isn't this bad? Don't others have any objections?"

When Fang Nixin was in the research group, she was more accustomed to people asking her to add her name. Now that Lu Cheng was suddenly feeding one of the authors of an article with great influence, she still felt a little guilty.

"Now the leadership of our research group is you and me, and everyone else is focusing on basic experiments."

"Okay, don't worry anymore. Your contribution to the research team is greater than theirs." Lu Cheng quickly ended the topic.

Fang Nixin looked at Lu Cheng seriously and said, "No, that student of yours, Dong Zhen, may be better at data and statistics than me. She even has a deeper attainment in the field of mathematics than me."

.”

"It's just that my understanding in the field of medical research is a little higher than hers. I think you can bring her into the decision-making group, maybe it will work wonders."

Girls prefer to be praised, but Fang Nixin only likes to be told what she is really good at.
To be continued...